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Macleaya Cordata Sanguinarine Extract Powder


Pink plumepoppy (Macleaya Cordata (Willd) R. Br.) is a wild plant mainly growing in China, the whole herbal, especially in its fruits contains a lot of alkaloids, which are Sanguinarine and Chelerythrine, also some minority of Bocconine, protopine, α-allocryptopine etc. In the Macleaya cordata extract, the Sanguinarine and Chelerythrine are two important alkaloids holding a high percentage.

Sanguinarine (SG) has been reported to form DNA adducts in vitro and increase the levels of DNA single strand breaks in the blood and bone marrow of mice treated intraperitoneally with SG. Recently, we showed no genotoxic effects of orally administrated 120 mg/kg feed Macleaya cordata extract (a mixture of sanguinarine and chelerythrine) in pigs or rats in 90-day studies. The goal of this paper was to assess the possible genotoxicity of M. cordata extract when included as a dietary admixture to rodents at concentrations providing 600 mg/kg feed and 100, 7000 or 14000 mg/kg feed Sangrovit (natural feed additive containing M. cordata extract and powdered M. cordata) in a 90-day pilot study.

Macleaya cordata extract is a green pollution-free plant extract. It has a strong antimicrobial activity and wide antimicrobial spectrum, it has antimicrobial activity against coccus, bacillus, gram-positive and electronegative bacterium, and it has a stronger antimicrobial activity more than commonly berberine hydrochloride and penicillin against some bacteria. Use this product can help livestock effectively antimicrobial diarrhea, simulative bile and pancreatic secretion. This product is safe and effective. It is easy to dissolve in methanol and ethanol solution.